In-silico models of stem cell and developmental systems - Yaki Setty

Friday, 5 September, 2014 - 11:30 to 13:00
In recent years, we have used software engineering tools to develop reactive models to simulate and analyze the development of organs. The modeled systems embody highly complex and dynamic processes, by which a set of precursor stem cells proliferate, differentiate and move, to form a functioning tissue. Three organs from diverse evolutionary

organisms have been thus modeled: the mouse pancreas, the C. elegans gonad, and partial rodent brain development. Analysis and execution of the models provided dynamic representation of the development, anticipated known experimental results and proposed novel testable predictions. In my talk, I will discuss challenges, goals and achievement in this direction in science.